Genetic code variations in mitochondria: tRNA as a major determinant of genetic code plasticity

被引：51

作者：

Yokobori, S

Suzuki, T

Watanabe, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Frontier Sci, Dept Integrated Biosci, Bunkyo Ku, Tokyo 1138656, Japan

[2] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Dept Mol Biol, Tokyo 1920392, Japan

[3] Univ Tokyo, Grad Sch Engn, Dept Chem & Biotechnol, Bunkyo Ku, Tokyo 1138656, Japan

来源：

JOURNAL OF MOLECULAR EVOLUTION | 2001年 / 53卷 / 4-5期

关键词：

codon capture; tRNA; mitochondria; wobble rule; competition;

D O I：

10.1007/s002390010221

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Characteristic features of tRNA such as the anticodon sequence and modified nucleotides in the anticodon loop are thought to be crucial effectors for promoting or restricting codon reassignment. Our recent findings on basepairing rules between anticodon and codon in various metazoan mitochondria suggest that the complete loss of a codon is not necessarily essential for codon reassignment to take place. We postulate that a possible competition between two tRNAs with cognate anticodon sequences towards the relevant codon to be varied has a potential role in codon reassignment. Our proposition can be viewed as an expanded version of the codon capture theory proposed by Osawa and Jukes.

引用

页码：314 / 326

页数：13

共 95 条

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