Inhibitory effect of heliantriol C; a component of edible Chrysanthemum, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin

被引：23

作者：

Yasukawa, K

Akihisa, T

Kasahara, Y

Ukiya, M

Kumaki, K

Tamura, T

Yamanouchi, S

Takido, M

机构：

[1] Nihon Univ, Coll Pharm, Funabashi, Chiba 274, Japan

[2] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 101, Japan

[3] Yamagata Prefectural Inst Publ Hlth, Yamagata, Japan

来源：

PHYTOMEDICINE | 1998年 / 5卷 / 03期

关键词：

antitumor promoter; two-stage carcinogenesis; 12-O-tetradecanoylphorbol-13-acetate; heliantriol C; faradiol; taraxastane-type triterpene; Chrysanthemum Asteraceae;

D O I：

10.1016/S0944-7113(98)80031-7

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two hydroxy taraxastane-type triterpenes, faradiol and heliantriol C, have been isolated from the ligulate flowers of Chrysanthemum morifolium Ramat. var, sinense Makino fa. esculentum Makino, the edible Chrysanthemum. These compounds showed strong inhibitory activity against 12-O-tetradecanoyl-phorbol-13-aetate (TPA)-induced inflammation in mice. At 0.2 mu mol/mouse, these compounds markedly inhibited the promoting effect of TPA (1 mu g/mouse) on skin tumor formation followed by 7,12-dimethylbenz[a]anthracene (50 mu g/mouse).

引用

页码：215 / 218

页数：4

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