Expression of gamma interferon by simian immunodeficiency virus increases attenuation and reduces postchallenge virus load in vaccinated rhesus macaques

被引:58
作者
Giavedoni, L [1 ]
Ahmad, S [1 ]
Jones, L [1 ]
Yilma, T [1 ]
机构
[1] UNIV CALIF DAVIS,SCH VET MED,DEPT VET PATHOL MICROBIOL & IMMUNOL,DAVIS,CA 95616
关键词
D O I
10.1128/JVI.71.2.866-872.1997
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Simian immunodeficiency virus (SIV) infection of macaques is a model for human immunodeficiency virus (HIV) infection. We have previously reported the construction and characterization of an SIV vector with a deletion in the nef gene (SIVDelta nef) and expressing gamma interferon (SIVHyIFN) (L. Giavedoni and T. Yilma, J. Virol. 70:2247-2251, 1996). We now show that rhesus macaques vaccinated with SIVHyIFN have a lower viral load than a group similarly immunized with SIVDelta nef. Viral loads remained low in the SIVHyIFN-vaccinated group even though SIV expressing gamma interferon could not be isolated after 6 weeks postimmunization in these animals. All immunized and two naive control macaques became infected when challenged with virulent SIVmac251 at 25 weeks postvaccination. In contrast to the two naive controls that died by 12 and 18 weeks postchallenge, all vaccinated animals remained healthy for more than 32 weeks. In addition, postchallenge cell-associated virus load was significantly lower in SIVHyIFN-immunized animals than in the group vaccinated with SIVDelta nef. These findings indicate that cytokine-expressing viruses can provide a novel approach for development of safe and efficacious live attenuated vaccines for AIDS.
引用
收藏
页码:866 / 872
页数:7
相关论文
共 33 条
[21]   IMMUNODEFICIENT MICE RECOVER FROM INFECTION WITH VACCINIA VIRUS EXPRESSING INTERFERON-GAMMA [J].
KOHONENCORISH, MRJ ;
KING, NJC ;
WOODHAMS, CE ;
RAMSHAW, IA .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (01) :157-161
[22]   TITRATION AND CHARACTERIZATION OF 2 RHESUS-DERIVED SIVMAC CHALLENGE STOCKS [J].
LEWIS, MG ;
BELLAH, S ;
MCKINNON, K ;
YALLEYOGUNRO, J ;
ZACK, PM ;
ELKINS, WR ;
DESROSIERS, RC ;
EDDY, GA .
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (02) :213-220
[23]   DEVELOPMENT OF SIMIAN IMMUNODEFICIENCY VIRUS ISOLATION, TITRATION, AND NEUTRALIZATION ASSAYS WHICH USE WHOLE-BLOOD FROM RHESUS-MONKEYS AND AN ANTIGEN CAPTURE ENZYME-LINKED-IMMUNOSORBENT-ASSAY [J].
LOHMAN, BL ;
HIGGINS, J ;
MARTHAS, ML ;
MARX, PA ;
PEDERSEN, NC .
JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (10) :2187-2192
[24]   A PARTIALLY ATTENUATED SIMIAN IMMUNODEFICIENCY VIRUS INDUCES HOST IMMUNITY THAT CORRELATES WITH RESISTANCE TO PATHOGENIC VIRUS CHALLENGE [J].
LOHMAN, BL ;
MCCHESNEY, MB ;
MILLER, CJ ;
MCGOWAN, E ;
JOYE, SM ;
VANROMPAY, KKA ;
REAY, E ;
ANTIPA, L ;
PEDERSEN, NC ;
MARTHAS, ML .
JOURNAL OF VIROLOGY, 1994, 68 (11) :7021-7029
[25]   EFFECTS OF INTERFERON IN MALARIA INFECTION [J].
MAHESHWARI, RK ;
SRIKANTAN, V ;
BHARTIYA, D ;
PURI, SK ;
DUTTA, GP ;
DHAWAN, BN .
IMMUNOLOGY LETTERS, 1990, 25 (1-3) :53-58
[26]  
MORILL JC, 1991, J INTERFERON RES, V11, P297
[27]   A FORMALIN-INACTIVATED WHOLE SIV VACCINE CONFERS PROTECTION IN MACAQUES [J].
MURPHEYCORB, M ;
MARTIN, LN ;
DAVISONFAIRBURN, B ;
MONTELARO, RC ;
MILLER, M ;
WEST, M ;
OHKAWA, S ;
BASKIN, GB ;
ZHANG, JY ;
PUTNEY, SD ;
ALLISON, AC ;
EPPSTEIN, DA .
SCIENCE, 1989, 246 (4935) :1293-1297
[28]   RECOVERY OF IMMUNODEFICIENT MICE FROM A VACCINIA VIRUS-IL-2 RECOMBINANT INFECTION [J].
RAMSHAW, IA ;
ANDREW, ME ;
PHILLIPS, SM ;
BOYLE, DB ;
COUPAR, BEH .
NATURE, 1987, 329 (6139) :545-546
[29]  
REED L. J., 1938, AMER JOUR HYG, V27, P493
[30]   SIMIAN IMMUNODEFICIENCY VIRUS (SIV) INFECTION OF INFANT RHESUS MACAQUES AS A MODEL TO TEST ANTIRETROVIRAL DRUG PROPHYLAXIS AND THERAPY - ORAL 3'-AZIDO-3'-DEOXYTHYMIDINE PREVENTS SIV INFECTION [J].
VANROMPAY, KKA ;
MARTHAS, ML ;
RAMOS, RA ;
MANDELL, CP ;
MCGOWAN, EK ;
JOYE, SM ;
PEDERSEN, NC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (11) :2381-2386