Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells

被引：49

作者：

Hagiwara, Yuki ^{[1
,2
]}

Kasukabe, Takashi ^{[1
]}

Kaneko, Yasuhiko ^{[1
]}

Niitsu, Nozomi ^{[2
]}

Okabe-Kado, Junko ^{[1
]}

机构：

[1] Saitama Canc Ctr, Res Inst Clin Oncol, Ina, Saitama 3620806, Japan

[2] Saitama Med Univ, Int Med Ctr, Ctr Comprehens Canc, Dept Hematol, Hidaka, Saitama 3501298, Japan

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2010年 / 92卷 / 01期

基金：

日本学术振兴会;

关键词：

Ellagic acid; Acute myeloid leukemia cells; Apoptosis; Caspase; Differentiation; ATRA; CHEMOPREVENTIVE AGENTS; MYELOID-LEUKEMIA; CANCER-CELLS; G1; ARREST; ANTIOXIDANT; EXPRESSION; THERAPY; LIGAND; PROLIFERATION; PUNICALAGIN;

D O I：

10.1007/s12185-010-0627-4

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

All-trans retinoic acid (ATRA) is a standard drug used for differentiation therapy in acute promyelocytic leukemia. To potentiate this therapy, we examined the effect of ellagic acid (EA), a natural polyphenolic compound with antiproliferative and antioxidant properties, on the growth and differentiation of HL-60 acute myeloid leukemia cells. EA was found to induce apoptosis, which was blocked by pan-caspase inhibitor, Z-VAD-FMK. EA activated the caspase-3 pathway and enhanced the expressions of myeloid differentiation markers (CD11b, MRP-14 protein, granulocytic morphology) induced by ATRA treatment. These results indicate that EA is a potent apoptosis inducer and also effectively potentiates ATRA-induced myeloid differentiation of HL-60 cells.

引用

页码：136 / 143

页数：8

共 30 条

[1]

Dietary berries and ellagic acid prevent oxidative DNA damage and modulate expression of DNA repair genes [J].

Aiyer, Harini S. ;

Vadhanam, Manicka V. ;

Stoyanova, Radka ;

Caprio, Gerard D. ;

Clapper, Margie L. ;

Gupta, Ramesh C. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2008, 9 (03) :327-341

[2]

Safety and antitumor activity of recombinant soluble Apo2 ligand [J].

Ashkenazi, A ;

Pai, RC ;

Fong, S ;

Leung, S ;

Lawrence, DA ;

Masters, SA ;

Blackie, C ;

Chang, L ;

McMurtrey, AE ;

Hebert, A ;

DeForge, L ;

Koumenis, IL ;

Lewis, D ;

Harris, L ;

Bussiere, J ;

Koeppen, H ;

Shahrokh, Z ;

Schwall, RH .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (02) :155-162

[3]

Death receptors: Signaling and modulation [J].

Ashkenazi, A ;

Dixit, VM .

SCIENCE, 1998, 281 (5381) :1305-1308

[4]

Targeting death and decoy receptors of the tumour-necrosis factor superfamily [J].

Ashkenazi, A .

NATURE REVIEWS CANCER, 2002, 2 (06) :420-430

[5]

Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL) [J].

Ashkenazi, Avi ;

Holland, Pamela ;

Eckhardt, S. Gail .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (21) :3621-3630

[6]

In vitro antiplasmodial activity of extracts of Alchornea cordifolia and identification of an active constituent:: ellagic acid [J].

Banzouzi, JT ;

Prado, R ;

Menan, H ;

Valentin, A ;

Roumestan, C ;

Mallie, M ;

Pelissier, Y ;

Blache, Y .

JOURNAL OF ETHNOPHARMACOLOGY, 2002, 81 (03) :399-401

[7]

CASTAIGNE S, 1990, BLOOD, V76, P1704

[8]

Role of chemopreventive agents in cancer therapy [J].

Dorai, T ;

Aggarwal, BB .

CANCER LETTERS, 2004, 215 (02) :129-140

[9]

Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells [J].

Edderkaoui, Mouad ;

Odinokova, Irina ;

Ohno, Izumi ;

Gukovsky, Ilya ;

Go, Vay Liang W. ;

Pandol, Stephen J. ;

Gukovskaya, Anna S. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (23) :3672-3680

[10]

Festa F, 2001, ANTICANCER RES, V21, P3903

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