Sugar codes for axons?

被引：87

作者：

Holt, CE

Dickson, BJ

机构：

[1] Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England

[2] Austrian Acad Sci, Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

NEURON | 2005年 / 46卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.neuron.2005.03.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Proteoglycans are complex macromolecules with the potential for extraordinary diversity. Several recent studies have demonstrated important roles for heparan sulfate and chondroitin sulfate proteoglycans (HSPGs and CSPGs) in axon pathfinding and have linked HSPGs to specific signaling pathways. More speculatively, there are hints of a "sugar code," in which specific sugar modifications might act instructively in guidance decisions. This raises the intriguing possibility that the complexity of neuronal wiring may in part reflect the complexity of proteoglycan modifications.

引用

收藏

页码：169 / 172

页数：4

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