Let me count the ways: Mechanisms of gene regulation by miRNAs and siRNAs

被引：310

作者：

Wu, Ligang ^{[1
,2
]}

Belasco, Joel G. ^{[1
,2
]}

机构：

[1] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst Biomol Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA

来源：

MOLECULAR CELL | 2008年 / 29卷 / 01期

关键词：

D O I：

10.1016/j.molcel.2007.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The downregulation of gene expression by miRNAs and siRNAs is a complex process involving both translational repression and accelerated mRNA turnover, each of which appears to occur by multiple mechanisms. Moreover, under certain conditions, miRNAs are also capable of activating translation. A variety of cellular proteins have been implicated in these regulatory mechanisms, yet their exact roles' remain largely unresolved.

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页码：1 / 7

页数：7

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