microRNA expression in erythropoiesis and erythroid disorders

被引：46

作者：

Lawrie, Charles H. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Clin Lab Sci, John Radcliffe Hosp, Lymphoid Malignancy Res Grp, Oxford OX3 9DU, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 150卷 / 02期

关键词：

microRNA; miRNA; erythroid; erythropoiesis; haematopoiesis; POLYCYTHEMIA-VERA; MEDIATED CONTROL; CD34(+) CELLS; SMALL RNAS; GENE; DIFFERENTIATION; LOCUS;

D O I：

10.1111/j.1365-2141.2009.07978.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>MicroRNAs are a recently discovered class of small (c. 22 nt) naturally occurring non-coding RNA molecules that regulate gene expression through binding to the un-translated region of target mRNA. MicroRNAs play key roles in many cellular pathways including haematopoiesis and aberrant expression is a common feature of haematological malignancies. Whilst other areas of haematopoiesis have been extensively reviewed the involvement of microRNAs in red cell production (erythropoiesis) and disorders of this pathway is lacking. In this review the rapidly accumulating evidence that points to the major role microRNAs play in both erythropoiesis and erythroid disorders is discussed.

引用

页码：144 / 151

页数：8

共 45 条

[21] Identification of erythropoietin-induced microRNAs in haematopoietic cells during erythroid differentiation [J].

Kosaka, Nobuyoshi ;

Sugiura, Keiichi ;

Yamamoto, Yusuke ;

Yoshioka, Yusuke ;

Miyazaki, Hiroshi ;

Komatsu, Norio ;

Ochiya, Takahiro ;

Kato, Takashi .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 142 (02) :293-300

[22] MicroRNAs and haematology: small molecules, big function [J].

Lawrie, Charles H. .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 137 (06) :503-512

[23] An extensive class of small RNAs in Caenorhabditis elegans [J].

Lee, RC ;

Ambros, V .

SCIENCE, 2001, 294 (5543) :862-864

[24] THE C-ELEGANS HETEROCHRONIC GENE LIN-4 ENCODES SMALL RNAS WITH ANTISENSE COMPLEMENTARITY TO LIN-14 [J].

LEE, RC ;

FEINBAUM, RL ;

AMBROS, V .

CELL, 1993, 75 (05) :843-854

[25] Prediction of mammalian microRNA targets [J].

Lewis, BP ;

Shih, IH ;

Jones-Rhoades, MW ;

Bartel, DP ;

Burge, CB .

CELL, 2003, 115 (07) :787-798

[26] Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets [J].

Lewis, BP ;

Burge, CB ;

Bartel, DP .

CELL, 2005, 120 (01) :15-20

[27] Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs [J].

Lim, LP ;

Lau, NC ;

Garrett-Engele, P ;

Grimson, A ;

Schelter, JM ;

Castle, J ;

Bartel, DP ;

Linsley, PS ;

Johnson, JM .

NATURE, 2005, 433 (7027) :769-773

[28] MicroRNA expression profiles classify human cancers [J].

Lu, J ;

Getz, G ;

Miska, EA ;

Alvarez-Saavedra, E ;

Lamb, J ;

Peck, D ;

Sweet-Cordero, A ;

Ebet, BL ;

Mak, RH ;

Ferrando, AA ;

Downing, JR ;

Jacks, T ;

Horvitz, HR ;

Golub, TR .

NATURE, 2005, 435 (7043) :834-838

[29] MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors [J].

Lu, Jun ;

Guo, Shangqin ;

Ebert, Benjamin L. ;

Zhang, Hao ;

Peng, Xiao ;

Bosco, Jocelyn ;

Pretz, Jennifer ;

Schlanger, Rita ;

Wang, Judy Y. ;

Mak, Raymond H. ;

Dombkowski, David M. ;

Preffer, Frederic I. ;

Scadden, David T. ;

Golub, Todd R. .

DEVELOPMENTAL CELL, 2008, 14 (06) :843-853

[30] Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTR [J].

Lytle, J. Robin ;

Yario, Therese A. ;

Steitz, Joan A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (23) :9667-9672

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