Chiral 1,4-bis-diphosphine ligands from optically active (Z)-olefines

被引：12

作者：

Cesarotti, Edoardo

Rimoldi, Isabella

Spalluto, Paola

Demartin, Francesco

机构：

[1] Univ Milan, Fac Farm, Dipartimento Chim Inorgan, I-20133 Milan, Italy

[2] Univ Milan, Fac Farm, Dipartimento Chim Strutturale & Sterochim Inorgan, I-20133 Milan, Italy

[3] Ist CNR ISTM, I-20133 Milan, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 11期

关键词：

D O I：

10.1016/j.tetasy.2007.04.018

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The catalytic asymmetric hydrogenation of prochiral ketones was carried out with Ru(II) complexes prepared from new chiral diphosphine ligands, cis-(R,R)-2,5-bis[(diarylphosphino)]-3-hexenes. These new ligands were prepared from enantiornerically pure (R,R) or (S,S)-(Z)-3-hexene-2,5 diol and enantionteric excesses up to 85% were obtained in the reduction of 2-benzamidomethyl-3-oxobutanoate, starting material for the synthesis of 4-acetoxy-2-azetidinone. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：1278 / 1283

页数：6

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