Overview of voltage-dependent calcium channels

被引：112

作者：

Jones, SW ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Physiol & Biophys, Cleveland, OH 44106 USA

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1998年 / 30卷 / 04期

关键词：

activation; inactivation; modulation; permeation; gating; secretion; contraction; neurotransmitter; G protein; second messenger;

D O I：

10.1023/A:1021977304001

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Voltage-dependent calcium channels couple electrical signals to cellular responses in excitable cells. Calcium channels are crucial for excitation-secretion coupling in neurons and endocrine cells, and excitation-contraction coupling in muscle. Several pharmacologically and kinetically distinct calcium channel types have been identified at the electrophysiological and molecular levels. This review summarizes the basic properties of voltage-dependent calcium channels, including mechanisms of ion permeation and block, gating kinetics, and modulation by G proteins and second messengers.

引用

页码：299 / 312

页数：14

共 133 条

[1] INTRACELLULAR CA2+ ACTIVATES A FAST VOLTAGE-SENSITIVE K+ CURRENT IN VERTEBRATE SYMPATHETIC NEURONS [J].

ADAMS, PR ;

CONSTANTI, A ;

BROWN, DA ;

CLARK, RB .

NATURE, 1982, 296 (5859) :746-749

[2]

ADLER EM, 1991, J NEUROSCI, V11, P1496

[3] INACTIVATION OF DELAYED OUTWARD CURRENT IN MOLLUSCAN NEURON SOMATA [J].

ALDRICH, RW ;

GETTING, PA ;

THOMPSON, SH .

JOURNAL OF PHYSIOLOGY-LONDON, 1979, 291 (JUN) :507-530

[4] NON-SELECTIVE CONDUCTANCE IN CALCIUM CHANNELS OF FROG-MUSCLE - CALCIUM SELECTIVITY IN A SINGLE-FILE PORE [J].

ALMERS, W ;

MCCLESKEY, EW .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 353 (AUG) :585-608

[5] 2 DISTINCT POPULATIONS OF CALCIUM CHANNELS IN A CLONAL LINE OF PITUITARY-CELLS [J].

ARMSTRONG, CM ;

MATTESON, DR .

SCIENCE, 1985, 227 (4682) :65-67

[6] OMEGA-CONOTOXIN GVIA BLOCKS A CA2+ CURRENT IN BOVINE CHROMAFFIN CELLS THAT IS NOT OF THE CLASSIC N-TYPE [J].

ARTALEJO, CR ;

PERLMAN, RL ;

FOX, AP .

NEURON, 1992, 8 (01) :85-95

[7] NEUROTRANSMITTER INHIBITION OF NEURONAL CALCIUM CURRENTS BY CHANGES IN CHANNEL VOLTAGE DEPENDENCE [J].

BEAN, BP .

NATURE, 1989, 340 (6229) :153-156

[8] FUNCTIONAL IMPACT OF SYNTAXIN ON GATING OF N-TYPE AND Q-TYPE CALCIUM CHANNELS [J].

BEZPROZVANNY, I ;

SCHELLER, RH ;

TSIEN, RW .

NATURE, 1995, 378 (6557) :623-626

[9] Structures and functions of calcium channel β subunits [J].

Birnbaumer, L ;

Qin, N ;

Olcese, R ;

Tareilus, E ;

Platano, D ;

Costantin, J ;

Stefani, E .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1998, 30 (04) :357-375

[10] Ca2+-dependent regulation in neuronal gene expression [J].

Bito, H ;

Deisseroth, K ;

Tsien, RW .

CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (03) :419-429

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