Overview of voltage-dependent calcium channels

被引：112

作者：

Jones, SW ^{[1
]}

机构：

[1] Case Western Reserve Univ, Dept Physiol & Biophys, Cleveland, OH 44106 USA

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1998年 / 30卷 / 04期

关键词：

activation; inactivation; modulation; permeation; gating; secretion; contraction; neurotransmitter; G protein; second messenger;

D O I：

10.1023/A:1021977304001

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Voltage-dependent calcium channels couple electrical signals to cellular responses in excitable cells. Calcium channels are crucial for excitation-secretion coupling in neurons and endocrine cells, and excitation-contraction coupling in muscle. Several pharmacologically and kinetically distinct calcium channel types have been identified at the electrophysiological and molecular levels. This review summarizes the basic properties of voltage-dependent calcium channels, including mechanisms of ion permeation and block, gating kinetics, and modulation by G proteins and second messengers.

引用

页码：299 / 312

页数：14

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