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First Streptococcus agalactiae isolates highly resistant to quinolones, with point mutations in gyrA and parC

被引：72
作者：
Kawamura, Y
Fujiwara, H
Mishima, N
Tanaka, Y
Tanimoto, A
Ilawa, S
Itoh, Y
Ezaki, T
机构：
[1] Gifu Univ, Grad Sch Med, Dept Microbial Bioinformat Regenerat & Adv Med Sc, Gifu 5008705, Japan
[2] Tottori Univ, Fac Med, Dept Pathophysiol & Therapeut Sci, Div Clin Lab Med, Yonago, Tottori 6838504, Japan
[3] Tottori Univ Hosp, Dept Clin Labs, Yonago, Tottori 6838504, Japan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 11期
关键词：
D O I：
10.1128/AAC.47.11.3605-3609.2003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Three isolates of Streptococcus agalactiae highly resistant to multiple fluoroquinolones were isolated in Japan. Compared with susceptible strains of S. agalactiae, these quinolone-resistant strains had double point mutations within the quinolone resistance-determining regions of gyrA and parC; Ser-81 was changed to Leu (TCA --> TTA) in the amino acid sequence deduced from gyrA, and Ser-79 was changed to Phe (TCC --> TTC) in the amino acid sequence deduced from parC. Comparative sequence analysis revealed the possibility of gene transfer between S. agalactiae and another beta-hemolytic streptococcus, Streptococcus difficile.
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页码：3605 / 3609
页数：5
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