SL trans-splicing: easy come or easy go?

被引：146

作者：

Hastings, KEM

机构：

[1] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada

[2] McGill Univ, Dept Biol, Montreal, PQ H3A 2B4, Canada

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/j.tig.2005.02.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Is spliced-leader (SL) trans-splicing an ancestral eukaryotic characteristic that has been lost in multiple lineages, or did it arise independently in the various phyla in which it occurs? Recent studies have discovered SL trans-splicing in new metazoan phyla, including the chordates. Its discovery in chordates identifies, for the first time, a phylum that clearly contains both trans-splicing and non-trans-splicing major groups, and defines a limited and well-understood field in which to study the evolutionary dynamics of SL trans-splicing. In this article, I summarize the evolutionarily relevant aspects of SL trans-splicing and consider the interplay among SL trans-splicing, pre-mRNA splice-signal syntax and evolutionary genomics.

引用

页码：240 / 247

页数：8

共 64 条

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