Role of peiroxisome proliferators-activated receptors in the pathogenesis and treatment of nonaloholic fatty liver disease

被引：129

作者：

Kallwitz, Eric R. ^{[1
]}

McLachlan, Alan ^{[2
]}

Cotler, Scott J. ^{[1
]}

机构：

[1] Univ Illinois, Dept Med 1, Chicago, IL USA

[2] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60680 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 01期

关键词：

non-alcoholic fatty liver disease; peroxisome proliferators-activated receptors; insulin resiatance; metabolic syndrome; pharmacologic ligands;

D O I：

10.3748/wjg.14.22

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent and can result in nonalcoholic steatohepatitis (NASH) and progressive liver disease including cirrhosis and hepatocellular carcinoma. A growing body of literature implicates the peroxisome proliferators-activated receptors (PPARs) in the pathogenesis and treatment of NAFLD. These nuclear hormone receptors impact on hepatic triglyceride accumulation and insulin resistance. The aim of this review is to describe the data linking PPAR alpha and PPAR gamma to NAFLD/NASH and to discuss the use of PPAR ligands for the treatment of NASH.

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页码：22 / 28

页数：7

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