Microevolution of Mycobacterium tuberculosis in a Tuberculosis Patient

被引:51
作者
Al-Hajoj, Sahal A. M. [1 ]
Akkerman, Onno [2 ]
Parwati, Ida [3 ]
Al-Gamdi, Saad [4 ]
Rahim, Zeaur [5 ]
van Soolingen, Dick [6 ]
van Ingen, Jakko [6 ]
Supply, Philip [7 ,8 ]
van der Zanden, Adri G. M. [9 ]
机构
[1] King Faisal Specialist Hosp & Res Ctr, Dept Comparat Med, Riyadh 11211, Saudi Arabia
[2] Med Spectrum Twente Hosp, Dept Pulmonol, Enschede, Netherlands
[3] Padjadjaran State Univ, Dr Hasan Sadikin Hosp, Dept Clin Pathol, Bandung, Indonesia
[4] Hera Gen Hosp, Mol Diagnost Unit, Mecca, Saudi Arabia
[5] Int Ctr Diarrhoeal Dis Res, Dhaka 1212, Bangladesh
[6] Natl Inst Publ Hlth & Environm, Natl TB Reference Lab, NL-3720 BA Bilthoven, Netherlands
[7] Univ Lille Nord France, Ctr Infect & Immun Lille, INSERM, Inst Pasteur Lille,CNRS,U1019,UMR 8204, Lille, France
[8] Genoscreen, Lille, France
[9] Lab Med Microbiol & Publ Hlth, Enschede, Netherlands
关键词
MOLECULAR EPIDEMIOLOGY; GENETIC DIVERSITY; REPETITIVE UNITS; STRAINS; INFECTION; SYSTEM; IDENTIFICATION; STABILITY; PATTERNS; REPEATS;
D O I
10.1128/JCM.00556-10
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Five Mycobacterium tuberculosis isolates were obtained from three body sites from a Dutch patient. The isolates displayed a single genotype by 24-locus MIRU-VNTR typing (except for a single locus not amplified from one isolate) but were differentiated by small variations in IS6110 fingerprints, spoligotypes, 6 hypervariable MIRU-VNTR loci, and/or DiversiLab profiles, revealing patterns of microevolution in a clonal infection.
引用
收藏
页码:3813 / 3816
页数:4
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