Genome3D: exploiting structure to help users understand their sequences

被引：31

作者：

Lewis, Tony E. ^{[1
]}

Sillitoe, Ian ^{[1
]}

Andreeva, Antonina ^{[2
]}

Blundell, Tom L. ^{[3
]}

Buchan, Daniel W. A. ^{[4
]}

Chothia, Cyrus ^{[2
]}

Cozzetto, Domenico ^{[4
]}

Dana, Jose M. ^{[5
]}

Filippis, Ioannis ^{[6
]}

Gough, Julian ^{[7
]}

Jones, David T. ^{[1
,4
]}

Kelley, Lawrence A. ^{[6
]}

Kleywegt, Gerard J. ^{[5
]}

Minneci, Federico ^{[4
]}

Mistry, Jaina ^{[5
]}

Murzin, Alexey G. ^{[2
]}

Ochoa-Montano, Bernardo ^{[3
]}

Oates, Matt E. ^{[7
]}

Punta, Marco ^{[5
]}

Rackham, Owen J. L. ^{[8
]}

Stahlhacke, Jonathan ^{[7
]}

Sternberg, Michael J. E. ^{[6
]}

Velankar, Sameer ^{[5
]}

Orengo, Christine ^{[1
]}

机构：

[1] UCL, Inst Struct & Mol Biol, London WC1E 6BT, England

[2] MRC Lab Mol Biol, Cambridge CB2 0QH, England

[3] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[4] UCL, Dept Comp Sci, London WC1E 6BT, England

[5] European Bioinformat Inst, Hinxton CB10 1SD, Cambs, England

[6] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Ctr Bioinformat, London SW7 2AZ, England

[7] Univ Bristol, Dept Comp Sci, Bristol BS8 1UB, Avon, England

[8] Hammersmith Hosp, MRC Clin Sci Ctr, London W12 0NN, England

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

PROTEIN; SUPERFAMILY; RECOGNITION; SCOP; CATH;

D O I：

10.1093/nar/gku973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genome3D (http://www.genome3d.eu) is a collaborative resource that provides predicted domain annotations and structural models for key sequences. Since introducing Genome3D in a previous NAR paper, we have substantially extended and improved the resource. We have annotated representatives from Pfam families to improve coverage of diverse sequences and added a fast sequence search to the website to allow users to find Genome3D-annotated sequences similar to their own. We have improved and extended the Genome3D data, enlarging the source data set from three model organisms to 10, and adding VIVACE, a resource new to Genome3D. We have analysed and updated Genome3D's SCOP/CATH mapping. Finally, we have improved the superposition tools, which now give users a more powerful interface for investigating similarities and differences between structural models.

引用

页码：D382 / D386

页数：5

共 12 条

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