TRPV4 calcium entry channel: a paradigm for gating diversity

被引：368

作者：

Nilius, B ^{[1
]}

Vriens, J ^{[1
]}

Prenen, J ^{[1
]}

Droogmans, G ^{[1
]}

Voets, T ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Physiol, Fysiol Lab, B-3000 Louvain, Belgium

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2004年 / 286卷 / 02期

关键词：

transient receptor potential; calcium channels; vanilloid receptor;

D O I：

10.1152/ajpcell.00365.2003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vanilloid receptor-1 (VR1, now TRPV1) was the founding member of a subgroup of cation channels within the TRP family. The TRPV subgroup contains six mammalian members, which all function as Ca2+ entry channels gated by a variety of physical and chemical stimuli. TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is activated by hypotonic cell swelling, heat, synthetic 4alpha-phorbols, and several endogenous substances including arachidonic acid (AA), the endocannabinoids anandamide and 2-AG, and cytochrome P-450 metabolites of AA, such as epoxyeicosatrienoic acids. This review summarizes data on TRPV4 as a paradigm of gating diversity in this subfamily of Ca2+ entry channels.

引用

页码：C195 / C205

页数：11

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