TRPV4 calcium entry channel: a paradigm for gating diversity

被引：368

作者：

Nilius, B ^{[1
]}

Vriens, J ^{[1
]}

Prenen, J ^{[1
]}

Droogmans, G ^{[1
]}

Voets, T ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Physiol, Fysiol Lab, B-3000 Louvain, Belgium

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2004年 / 286卷 / 02期

关键词：

transient receptor potential; calcium channels; vanilloid receptor;

D O I：

10.1152/ajpcell.00365.2003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vanilloid receptor-1 (VR1, now TRPV1) was the founding member of a subgroup of cation channels within the TRP family. The TRPV subgroup contains six mammalian members, which all function as Ca2+ entry channels gated by a variety of physical and chemical stimuli. TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is activated by hypotonic cell swelling, heat, synthetic 4alpha-phorbols, and several endogenous substances including arachidonic acid (AA), the endocannabinoids anandamide and 2-AG, and cytochrome P-450 metabolites of AA, such as epoxyeicosatrienoic acids. This review summarizes data on TRPV4 as a paradigm of gating diversity in this subfamily of Ca2+ entry channels.

引用

页码：C195 / C205

页数：11

共 106 条

[71] P-450 metabolites of arachidonic acid in the control of cardiovascular function [J].

Roman, RJ .

PHYSIOLOGICAL REVIEWS, 2002, 82 (01) :131-185

[72] The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1) [J].

Smart, D ;

Gunthorpe, MJ ;

Jerman, JC ;

Nasir, S ;

Gray, J ;

Muir, AI ;

Chambers, JK ;

Randall, AD ;

Davis, JB .

BRITISH JOURNAL OF PHARMACOLOGY, 2000, 129 (02) :227-230

[73] TRPV3 is a temperature-sensitive vanilloid receptor-like protein [J].

Smith, GD ;

Gunthorpe, J ;

Kelsell, RE ;

Hayes, PD ;

Reilly, P ;

Facer, P ;

Wright, JE ;

Jerman, JC ;

Walhin, JP ;

Ooi, L ;

Egerton, J ;

Charles, KJ ;

Smart, D ;

Randall, AD ;

Anand, P ;

Davis, JB .

NATURE, 2002, 418 (6894) :186-190

[74] OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity [J].

Strotmann, R ;

Harteneck, C ;

Nunnenmacher, K ;

Schultz, G ;

Plant, TD .

NATURE CELL BIOLOGY, 2000, 2 (10) :695-702

[75] Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site [J].

Strotmann, R ;

Schultz, G ;

Plant, TD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (29) :26541-26549

[76] Impaired pressure sensation in mice lacking TRPV4 [J].

Suzuki, M ;

Mizuno, A ;

Kodaira, K ;

Imai, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (25) :22664-22668

[77] Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1 [J].

Szallasi, A ;

Szabó, T ;

Bíró, T ;

Modarres, S ;

Blumberg, PM ;

Krause, JE ;

Cortright, DN ;

Appendino, G .

BRITISH JOURNAL OF PHARMACOLOGY, 1999, 128 (02) :428-434

[78]

Szallasi A, 1999, PHARMACOL REV, V51, P159

[79] Impairment of store-operated Ca2+ entry in TRPC4-/- mice interferes with increase in lung microvascular permeability [J].

Tiruppathi, C ;

Freichel, M ;

Vogel, SM ;

Paria, BC ;

Mehta, D ;

Flockerzi, V ;

Malik, AB .

CIRCULATION RESEARCH, 2002, 91 (01) :70-76

[80] Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C-elegans neurons [J].

Tobin, DM ;

Madsen, DM ;

Kahn-Kirby, A ;

Peckol, EL ;

Moulder, G ;

Barstead, R ;

Maricq, AV ;

Bargmann, CI .

NEURON, 2002, 35 (02) :307-318

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