Psammaplysenes C and D, cytotoxic alkaloids from Psammoclemma sp.

被引：19

作者：

Buchanan, Malcolm S.

Carroll, Anthony R.

Addepalli, Rama

Avery, Vicky M.

Hooper, John N. A.

Quinn, Ronald J. ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Queensland Museum, Queensland Ctr Biodivers, Brisbane, Qld 4101, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 11期

关键词：

D O I：

10.1021/np0703646

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The sponge Psammoclemma sp. was investigated as part of our studies to discover P2X(7) receptor antagonists for the treatment of inflammatory disease. The biological activity of this extract was found to be due to the cytotoxicity of two new bromotyrosine alkaloids, psammaplysenes C (1) and D (2), and not P2X(7)-specific activity. Their structures were determined by 1D and 2D NMR spectroscopy.

引用

页码：1827 / 1829

页数：3

共 7 条

[1] CHEMISTRY OF VERONGIDA SPONGES .1. CONSTITUENTS OF THE CARIBBEAN SPONGE PSEUDOCERATINA-CRASSA [J].