Heterogeneity of thymic dendritic cells

被引：126

作者：

Wu, L ^{[1
]}

Shortman, K ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 04期

基金：

英国医学研究理事会;

关键词：

thymus; dendritic cell; plasmacytoid dendritic cell; dendritic cell development; thymocyte selection;

D O I：

10.1016/j.smim.2005.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thymus is the site of generation and selection of T-lymphocytes. It also contains phenotypically and functionally distinct dendritic cell (DC) populations, including conventional DC (cDC) and plasmacytoid DC (pDC). Thymic cDC are heterogeneous and contain two subsets: a major subset derived from the precursors within thymus, and a minor subset presumably of extrathymic origin. Increasing evidence suggest that thymic cDC can cross-present self-antigens to developing thymocytes and play an important role in thymocyte negative selection and central tolerance induction. Thymic pDC can produce type-1 interferon upon appropriate activation. However, their role in a steady state thymus is currently unclear. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：304 / 312

页数：9

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