Stem cell-based composite tissue constructs for regenerative medicine

被引:116
作者
Rahaman, MN
Mao, JJ
机构
[1] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA
[2] Univ Missouri, Dept Mat Sci & Engn, Rolla, MO 65409 USA
[3] Univ Illinois, Tissue Engn Lab, Dept Bioengn, Chicago, IL 60612 USA
[4] Univ Illinois, Tissue Engn Lab, Dept Orthodont, Chicago, IL 60612 USA
[5] Univ Illinois, Dept Anat & Cell Biol, Coll Med, Chicago, IL 60612 USA
关键词
stem cells; biomaterials; tissue engineering; gene therapy; wound healing; regenerative medicine;
D O I
10.1002/bit.20292
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A major task of contemporary medicine and dentistry is restoration of human tissues and organs lost to diseases and trauma. A decade-long intense effort in tissue engineering has provided the proof of concept for cell-based replacement of a number of individual tissues such as the skin, cartilage, and bone. Recent work in stem cell-based in vivo restoration of multiple tissue phenotypes by composite tissue constructs such as osteochondral and fibro-osseous grafts has demonstrated probable clues for bioengineered replacement of complex anatomical structures consisting of multiple cell lineages such as the synovial joint condyle, tendon-bone complex, bone-ligament junction, and the periodontium. Of greater significance is a tangible contribution by current attempts to restore the structure and function of multitissue structures using cell-based composite tissue constructs to the understanding of ultimate biological restoration of complex organs such as the kidney or liver. The present review focuses on recent advances in stem cell-based composite tissue constructs and attempts to outline challenges for the manipulation of stem cells in tailored biomaterials in alignment with approaches potentially utilizable in regenerative medicine of human tissues and organs. (C) 2005 Wiley Periodicals, Inc.
引用
收藏
页码:261 / 284
页数:24
相关论文
共 286 条
[1]   Differential effects of insulin-like growth factor-I on matrix and DNA synthesis in various regions and types of rabbit tendons [J].
Abrahamsson, SO ;
Lohmander, S .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1996, 14 (03) :370-376
[2]   Formation of a mandibular condyle in vitro by tissue engineering [J].
Abukawa, H ;
Terai, H ;
Hannouche, D ;
Vacanti, JP ;
Kaban, LB ;
Troulis, MJ .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2003, 61 (01) :94-100
[3]  
Agrawal CM, 2001, J BIOMED MATER RES, V55, P141, DOI 10.1002/1097-4636(200105)55:2<141::AID-JBM1000>3.0.CO
[4]  
2-J
[5]   Evaluation of donor site intrinsic healing response in autologous osteochondral grafting of the knee [J].
Ahmad, CS ;
Guiney, WB ;
Drinkwater, CJ .
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 2002, 18 (01) :95-98
[6]   Guided tissue regeneration-based root coverage: Meta-analysis [J].
Al-Hamdan, K ;
Eber, R ;
Sarment, D ;
Kowalski, C ;
Wang, HL .
JOURNAL OF PERIODONTOLOGY, 2003, 74 (10) :1520-1533
[7]   Genetically engineered stem cell therapy for tissue regeneration [J].
Alessandri, G ;
Emanueli, C ;
Madeddu, P .
CARDIAC ENGINEERING: FROM GENES AND CELLS TO STRUCTURE AND FUNCTION, 2004, 1015 :271-284
[8]   Tissue-engineered osteochondral constructs in the shape of an articular condyle [J].
Alhadlaq, A ;
Mao, JJ .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2005, 87A (05) :936-944
[9]   Mesenchymal stem cells: Isolation and therapeutics [J].
Alhadlaq, A ;
Mao, JJ .
STEM CELLS AND DEVELOPMENT, 2004, 13 (04) :436-448
[10]   Adult stem cell driven genesis of human-shaped articular condyle [J].
Alhadlaq, A ;
Elisseeff, JH ;
Hong, L ;
Williams, CG ;
Caplan, AI ;
Sharma, B ;
Kopher, RA ;
Tomkoria, S ;
Lennon, DP ;
Lopez, A ;
Mao, JJ .
ANNALS OF BIOMEDICAL ENGINEERING, 2004, 32 (07) :911-923