Combinatorial libraries and biological discovery

被引：15

作者：

Gray, NS ^{[1
]}

机构：

[1] Novartis Inst Funct Genomics, San Diego, CA 92121 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0959-4388(00)00257-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Combinatorial chemistry has become a popular too] for the preparation of collections of compounds that can be used to find inhibitors and substrates for different protein targets. It has evolved to provide small molecule libraries, which, with the concomittant use of affinity chromatography, gene expression profiling and complementation, can be used to identify compounds and their protein targets in biological systems, including the neurological system.

引用

收藏

页码：608 / 614

页数：7

相关论文

共 46 条

[1] Profiling the specific reactivity of the proteome with non-directed activity-based probes [J].

Adam, GC ;

Cravatt, BF ;

Sorensen, EJ .

CHEMISTRY & BIOLOGY, 2001, 8 (01) :81-95

[2] Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin [J].

Backes, BJ ;

Harris, JL ;

Leonetti, F ;

Craik, CS ;

Ellman, JA .

NATURE BIOTECHNOLOGY, 2000, 18 (02) :187-193

[3] Recent developments in the encoding and deconvolution of combinatorial libraries [J].

Barnes, C ;

Balasubramanian, S .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2000, 4 (03) :346-350

[4] THE COMBINATORIAL SYNTHESIS AND CHEMICAL AND BIOLOGICAL EVALUATION OF A 1,4-BENZODIAZEPINE LIBRARY [J].

BUNIN, BA ;

PLUNKETT, MJ ;

ELLMAN, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :4708-4712

[5] Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors [J].

Chang, YT ;

Gray, NS ;

Rosania, GR ;

Sutherlin, DP ;

Kwon, S ;

Norman, TC ;

Sarohia, R ;

Leost, M ;

Meijer, L ;

Schultz, PG .

CHEMISTRY & BIOLOGY, 1999, 6 (06) :361-375

[6] Comprehensive survey of combinatorial library synthesis: 1999 [J].

Dolle, RE .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (05) :383-433

[7] Comprehensive survey of combinatorial library synthesis: 1998 [J].

Dolle, RE ;

Nelson, KH .

JOURNAL OF COMBINATORIAL CHEMISTRY, 1999, 1 (04) :235-282

[8] Recent advances in the preparation of heterocycles on solid support:: A review of the literature [J].

Franzén, RG .

JOURNAL OF COMBINATORIAL CHEMISTRY, 2000, 2 (03) :195-214

[9] Genomic profiling of drug sensitivities via induced haploinsufficiency [J].

Giaever, G ;

Shoemaker, DD ;

Jones, TW ;

Liang, H ;

Winzeler, EA ;

Astromoff, A ;

Davis, RW .

NATURE GENETICS, 1999, 21 (03) :278-283

[10] Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors [J].

Gray, NS ;

Wodicka, L ;

Thunnissen, AMWH ;

Norman, TC ;

Kwon, SJ ;

Espinoza, FH ;

Morgan, DO ;

Barnes, G ;

LeClerc, S ;

Meijer, L ;

Kim, SH ;

Lockhart, DJ ;

Schultz, PG .

SCIENCE, 1998, 281 (5376) :533-538

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