Cholesterol induced CTAB micelle-to-vesicle phase transitions

被引：67

作者：

Cano-Sarabia, Mary ^{[2
,3
]}

Angelova, Angelina ^{[1
]}

Ventosa, Nora ^{[2
,3
]}

Lesieur, Sylviane ^{[1
]}

Veciana, Jaume ^{[2
,3
]}

机构：

[1] Univ Paris Sud, CNRS, UMR 8612, Equipe Physicochim Syst Polyphases, F-92296 Chatenay Malabry, France

[2] CSIC, Inst Ciencia Mat Barcelona, Dept Mol Nanosci & Organ Mat, Cerdanyola Del Valles 08193, Catalonia, Spain

[3] CIBER BBN, Barcelona, Spain

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2010年 / 350卷 / 01期

关键词：

Cationic vesicle; Critical micellar concentration; Self-assembly; Phase transition mechanism; Cetyltrimethylammonium bromide; Cholesterol; OCTYL GLUCOSIDE; LECITHIN VESICLES; AQUEOUS-SOLUTIONS; SOLUBILIZATION; SURFACTANT; LIPOSOMES; BROMIDE; DETERGENT; WATER; DNA;

D O I：

10.1016/j.jcis.2010.04.069

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Vesicles prepared by self-assembly of a hydrated mixture of a cationic surfactant (cetyltrimethylammonium bromide) and a lipid (cholesterol) are studied as potential nanocarriers for the delivery of active ingredients. The understanding of the mechanism of the micelle-to-vesicle transition involved in the vesicle formation appears to be crucial regarding the stability of the vesicles as nanovectors. Here, UV-Vis spectroscopy is used to monitor the phase transition from micelles to vesicles promoted by the progressive addition of cholesterol to CTAB micellar solutions. The employed solvatochromic indicator, pinacyanol chloride (PIN), is a cyanine dye that is highly sensitive to the polarity of the medium. The self-assembly between the CTAB and the cholesterol molecules is investigated by means of turbidity (optical density) measurements as well. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：10 / 15

页数：6

共 48 条

[1] Microstructure evolution in aqueous solutions of cetyl trimethylammonium bromide (CTAB) and phenol derivatives [J].