Inhibition of src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines

被引：19

作者：

Boschelli, DH

Powell, D

Golas, JM

Boschelli, F

机构：

[1] Wyeth Res, Chem & Screening Sci, Pearl River, NY 10965 USA

[2] Wyeth Res, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(03)00628-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

4-(2,4-Dichloro-5-methoxy)anilino-5,10-dihydropyrimido[4,5-b]quinolines are potent inhibitors of Src kinase and Src cellular activity while having no effect on Fyn cellular activity. The corresponding 4-(2,4-dichloro-5-methoxy)anilino-pyrimido[4,5-b] quinolines are much less effective Src inhibitors. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：2977 / 2980

页数：4

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