HSP90 and the chaperoning of cancer

被引：2007

作者：

Whitesell, L ^{[1
]}

Lindquist, SL

机构：

[1] Univ Arizona, Steele Mem Childrens Res Ctr, Tucson, AZ 85724 USA

[2] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 10期

关键词：

D O I：

10.1038/nrc1716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Standing watch over the proteome, molecular chaperones are an ancient and evolutionarily conserved class of proteins that guide the normal folding, intracellular disposition and proteolytic turnover of many of the key regulators of cell growth, differentiation and survival. This essential guardian function is subverted during oncogenesis to allow malignant transformation and to facilitate rapid somatic evolution. Pharmacologically 'bribing' the essential guard duty of the chaperone HSP90 (heat-shock protein of 90 kDa) seems to offer a unique anticancer strategy of considerable promise.

引用

页码：761 / 772

页数：12

共 147 条

[51] Differential expression of 70-kDa heat shock-protein in human oral tumorigenesis [J].

Kaur, J ;

Ralhan, R .

INTERNATIONAL JOURNAL OF CANCER, 1995, 63 (06) :774-779

[52] DT-diaphorase expression and tumor cell sensitivity to 17-allylamino,17-demethoxygeldanamycin, an inhibitor of heat shock protein 90 [J].

Kelland, LR ;

Sharp, SY ;

Rogers, PM ;

Myers, TG ;

Workman, P .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1999, 91 (22) :1940-1949

[53] Development of a fluorescence polarization assay for the molecular chaperone Hsp90 [J].

Kim, J ;

Felts, S ;

Llauger, L ;

He, HZ ;

Huezo, H ;

Rosen, H ;

Chiosis, G .

JOURNAL OF BIOMOLECULAR SCREENING, 2004, 9 (05) :375-381

[54] CORRELATION OF THE SURVIVAL OF OVARIAN-CANCER PATIENTS WITH MESSENGER-RNA EXPRESSION OF THE 60-KD HEAT-SHOCK PROTEIN HSP-60 [J].

KIMURA, E ;

ENNS, RE ;

ALCARAZ, JE ;

ARBOLEDA, J ;

SLAMON, DJ ;

HOWELL, SB .

JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (05) :891-898

[55] Synthesis and evaluation of geldanamycin-testosterone hybrids [J].

Kuduk, SD ;

Harris, CR ;

Zheng, FZF ;

Sepp-Lorenzino, L ;

Ouerfelli, Q ;

Rosen, N ;

Danishefsky, SJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (11) :1303-1306

[56]

LeBlanc R, 2002, CANCER RES, V62, P4996

[57] Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin [J].

Lee, YS ;

Marcu, MG ;

Neckers, L .

CHEMISTRY & BIOLOGY, 2004, 11 (07) :991-998

[58] Heat shock response - Pathophysiological implications [J].

Leppa, S ;

Sistonen, L .

ANNALS OF MEDICINE, 1997, 29 (01) :73-78

[59] Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia [J].

Lu, AG ;

Ran, RQ ;

Parmentier-Batteur, S ;

Nee, A ;

Sharp, FR .

JOURNAL OF NEUROCHEMISTRY, 2002, 81 (02) :355-364

[60] Genes and Proteins Governing the Cellular Sensitivity to HSP90 Inhibitors: A Mechanistic Perspective [J].

Maloney, Alison ;

Clarke, Paul A. ;

Workman, Paul .

CURRENT CANCER DRUG TARGETS, 2003, 3 (05) :331-341

← 1 2 3 4 5 6 7 8 9 10 →