A convenient method for the synthesis of N-hydroxyureas

被引：21

作者：

Parrish, DA ^{[1
]}

Zou, Z ^{[1
]}

Allen, CL ^{[1
]}

Day, CS ^{[1
]}

King, SB ^{[1
]}

机构：

[1] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 51期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

N-hydroxyureas; nitric oxide; nitric oxide donors; carbohydrates; hydrogenation;

D O I：

10.1016/j.tetlet.2005.10.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of amines with 1-(4-nitrophenol)-N-(O-benzylhydroxy)carbamate yields the O-benzyl protected N-hydroxyureas. Hydrogenation of the O-benzyl protected N-hydroxyureas over 5% Pd/BaSO4 cleanly gives the N-hydroxyureas ill good yield. In addition to primary and secondary aliphatic and aromatic amines, this method converts amino sugars to the corresponding N-hydroxyureas without extensive protecting group chemistry. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8841 / 8843

页数：3

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