The effect of 2′-fluorine substitutions on DNA i-motif conformation and stability

被引：24

作者：

Fenna, Clare P. ^{[2
]}

Wilkinson, Victoria J. ^{[2
]}

Arnold, John R. P. ^{[2
]}

Cosstick, Richard ^{[1
]}

Fisher, Julie ^{[2
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 30期

关键词：

D O I：

10.1039/b804833a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(1)H and (19)F NMR, and UV thermal melting studies have established that the stability of d(TCCCCC) is enhanced by the inclusion of a single 2'-fluorine-modified deoxycytidine residue; the results support the notion of the importance of sugar-sugar contacts in stabilising i-motifs in general and reveal that solvation is the cause of the instability of RNA equivalents.

引用

页码：3567 / 3569

页数：3

共 22 条

[1] DNA nanomachines and nanostructures involving quadruplexes [J].

Alberti, Patrizia ;

Bourdoncle, Anne ;

Sacca, Barbara ;

Lacroix, Laurent ;

Mergny, Jean-Louis .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2006, 4 (18) :3383-3391

[2] Observation of 18O solvent-induced isotope shifts in 19F NMR signals [J].

Arnold, JRP ;

Fisher, J .

CHEMICAL COMMUNICATIONS, 1998, (17) :1859-1860

[3] The H218O solvent-induced isotope shift in 19F NMR [J].

Arnold, JRP ;

Fisher, J .

JOURNAL OF MAGNETIC RESONANCE, 2000, 142 (01) :1-10

[4] The polar hydrophobicity of fluorinated compounds [J].

Biffinger, JC ;

Kim, HW ;

DiMagno, SG .

CHEMBIOCHEM, 2004, 5 (05) :622-627

[5] NUCLEOSIDE CONFORMATIONS .16. NUCLEAR MAGNETIC-RESONANCE AND CIRCULAR-DICHROISM STUDIES ON PYRIMIDINE-2'-FLUORO-2'-DEOXYRIBONUCLEOSIDES [J].

BLANDIN, M ;

SON, TD ;

CATLIN, JC ;

GUSCHLBAUER, W .

BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 361 (03) :249-256

[6] Stabilization of the DNA I-motif structure by incorporation of 3′-S-phosphorothiolate linkages [J].

Brazier, JA ;

Fisher, J ;

Cosstick, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (01) :114-117

[7] The RNA2-PNA2 hybrid i-motif -: a novel RNA-based building block [J].

Chakraborty, Saikat ;

Modi, Souvik ;

Krishnan, Yamuna .

CHEMICAL COMMUNICATIONS, 2008, (01) :70-72

[8] Stability of chimeric DNA/RNA cytosine tetrads: Implications for i-motif formation by RNA [J].

Collin, D ;

Gehring, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (17) :4069-4072

[9] Participation of yeast inosine 5′-monophosphate dehydrogenase in an in vitro complex with a fragment of the C-rich telomeric strand [J].

Cornuel, JF ;

Moraillon, A ;

Guéron, M .

BIOCHIMIE, 2002, 84 (04) :279-289

[10] Use of F-19 NMR to probe protein structure and conformational changes [J].

Danielson, MA ;

Falke, JJ .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1996, 25 :163-195

← 1 2 3 →