The effect of 2′-fluorine substitutions on DNA i-motif conformation and stability

被引：24

作者：

Fenna, Clare P. ^{[2
]}

Wilkinson, Victoria J. ^{[2
]}

Arnold, John R. P. ^{[2
]}

Cosstick, Richard ^{[1
]}

Fisher, Julie ^{[2
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 30期

关键词：

D O I：

10.1039/b804833a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(1)H and (19)F NMR, and UV thermal melting studies have established that the stability of d(TCCCCC) is enhanced by the inclusion of a single 2'-fluorine-modified deoxycytidine residue; the results support the notion of the importance of sugar-sugar contacts in stabilising i-motifs in general and reveal that solvation is the cause of the instability of RNA equivalents.

引用

页码：3567 / 3569

页数：3

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