Palladium-catalyzed coupling of pyrazole triflates with arylboronic acids

被引:54
作者
Dvorak, CA [1 ]
Rudolph, DA [1 ]
Ma, S [1 ]
Carruthers, NI [1 ]
机构
[1] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA
关键词
D O I
10.1021/jo0477897
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A general protocol for the palladium-mediated Suzuki coupling reaction of pyrazole triflates and aryl boronic acids has been developed. The use of additional dppf ligand was determined to increase product yields allowing for the use of a broad range of reaction substrates.
引用
收藏
页码:4188 / 4190
页数:3
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