Hepatitis C Virus: Assembly and Release of Virus Particles

被引：87

作者：

Jones, Daniel M. ^{[1
]}

McLauchlan, John ^{[1
]}

机构：

[1] MRC, Virol Unit, Glasgow G11 5JR, Lanark, Scotland

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 30期

基金：

英国医学研究理事会;

关键词：

NONSTRUCTURAL PROTEIN 5A; SIGNAL PEPTIDE PEPTIDASE; CORE PROTEIN; LIPID DROPLET; LOW-DENSITY; RNA REPLICATION; COMPENSATORY MUTATIONS; NONTRANSLATED REGION; TRANS-ENCAPSIDATION; CELL TRANSMISSION;

D O I：

10.1074/jbc.R110.133017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis C virus is a blood-borne virus that typically establishes a chronic infection in the liver, which often results in cirrhosis and hepatocellular carcinoma. Progress in understanding the complete virus life cycle has been greatly enhanced by the recent availability of a tissue culture system that produces infectious virus progeny. Thus, it is now possible to gain insight into the roles played by viral components in assembly and egress and the cellular pathways that contribute to virion formation. This minireview describes the key determining viral and host factors that are needed to produce infectious virus.

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收藏

页码：22732 / 22738

页数：7

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