Synthesis, crystal structures and biological activities of 2-acetylpyridine N(4)-cyclohexylthiosemicarbazone and its manganese (II) and nickel (II) complexes

被引：30

作者：

Li, Ming-Xue ^{[1
,2
]}

Zhang, Dong ^{[1
]}

Zhang, Li-Zhi ^{[1
]}

Niu, Jing-Yang ^{[1
]}

Ji, Bian-Sheng ^{[2
]}

机构：

[1] Henan Univ, Inst Mol & Crystal Engn, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China

[2] Henan Univ, Key Lab Nat Med & Immunoengn, Kaifeng 475004, Peoples R China

来源：

INORGANIC CHEMISTRY COMMUNICATIONS | 2010年 / 13卷 / 12期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Thiosemicarbazone; Complex; Crystal structure; Cytotoxic activity; COPPER(II) COMPLEXES; ANTITUMOR-ACTIVITY; THIOSEMICARBAZONES; PALLADIUM(II); COBALT(III); CHEMISTRY; IRON(III);

D O I：

10.1016/j.inoche.2010.08.032

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学];

摘要：

2-Acetylpyridine N(4)-cyclohexylthiosemicarbazone (HL) and its manganese(11) and nickel(11) complexes formulated as [Mn(L)(2)] (1) and [Ni(L)(2)] (2) have been synthesized and characterized by elemental analysis, infrared spectra, mass spectra, and single-crystal X-ray diffraction studies. In the two complexes, the coordination polyhedron approaches an octahedron, where the two ligands coordinate to the metal via the pyridine nitrogen atom and the nitrogen and sulfur donors of the thiosemicarbazide moiety. Biological studies, carried out in vitro against selected bacteria and K562 leukaemia cell line, respectively, have shown that the free ligand and its complexes exhibited distinct differences in the biological activities. (C) 2010 Elsevier B.V. All rights reserved.

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页码：1572 / 1575

页数：4

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