Zebrafish as a model for myelopoiesis during embryogenesis

被引：52

作者：

Berman, JN

Kanki, JP

Look, AT

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Childrens Hosp, Boston, MA 02115 USA

来源：

EXPERIMENTAL HEMATOLOGY | 2005年 / 33卷 / 09期

关键词：

D O I：

10.1016/j.exphem.2005.06.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Zebrafish produce nearly identical hematopoeitic cell lineages to those found in mammals and other higher vertebrates. As in mammals, blood cell development proceeds in distinct waves, constituting embryonic (primitive) and adult (definitive) hematopoiesis. The conservation of genes such as scl, pu.1, clebp alpha, mpo, l-plastic, and lysozyme C in myelopoiesis and the corresponding expression patterns in zebrafish suggests that shared genetic pathways regulate this complex developmental process. In the zebrafish model system, experimental approaches have been applied, including RNA in situ hybridzation, morpholino injections, and the analysis of mutant and transgenic fish lines, leading to improved understanding of the regulation in vivo of key molecular pathways with conserved roles in vertebrate myelopoiesis. (c) 2005 International Society for Experimental Hematology. Published by Elsevier Inc.

引用

收藏

页码：997 / 1006

页数：10

相关论文

共 98 条

[11] Characterization of embryonic globin genes of the zebrafish [J].

Brownlie, A ;

Hersey, C ;

Oates, AC ;

Paw, BH ;

Falick, AM ;

Witkowska, HE ;

Flint, J ;

Higgs, D ;

Jessen, J ;

Bahary, N ;

Zhu, H ;

Lin, S ;

Zon, L .

DEVELOPMENTAL BIOLOGY, 2003, 255 (01) :48-61

[12] Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators [J].

Burns, CE ;

DeBlasio, T ;

Zhou, Y ;

Zhang, J ;

Zon, L ;

Nimer, SD .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (12) :1381-1389

[13] Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells [J].

Buske, C ;

Feuring-Buske, M ;

Abramovich, C ;

Spiekermann, K ;

Eaves, CJ ;

Coulombel, L ;

Sauvageau, G ;

Hogge, DE ;

Humphries, RK .

BLOOD, 2002, 100 (03) :862-868

[14] THE TAL-GENE UNDERGOES CHROMOSOME-TRANSLOCATION IN T-CELL LEUKEMIA AND POTENTIALLY ENCODES A HELIX LOOP HELIX PROTEIN [J].

CHEN, Q ;

CHENG, JT ;

TSAI, LH ;

SCHNEIDER, N ;

BUCHANAN, G ;

CARROLL, A ;

CRIST, W ;

OZANNE, B ;

SICILIANO, MJ ;

BAER, R .

EMBO JOURNAL, 1990, 9 (02) :415-424

[15] Transposon vectors for gene-trap insertional mutagenesis in vertebrates [J].

Clark, KJ ;

Geurts, AM ;

Bell, JB ;

Hackett, PB .

GENESIS, 2004, 39 (04) :225-233

[16] cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes [J].

Davidson, AJ ;

Ernst, P ;

Wang, Y ;

Dekens, MPS ;

Kingsley, PD ;

Palis, J ;

Korsmeyer, SJ ;

Daley, GQ ;

Zon, LI .

NATURE, 2003, 425 (6955) :300-306

[17]

DAVIDSON AJ, 2004, BLOOD, V104

[18] Bone morphogenetic proteins act synergistically with haematopoietic cytokines in the differentiation of haematopoietic progenitors [J].

Detmer, K ;

Walker, AN .

CYTOKINE, 2002, 17 (01) :36-42

[19] INTRAEMBRYONIC HEMATOPOIETIC-CELL MIGRATION DURING VERTEBRATE DEVELOPMENT [J].

DETRICH, HW ;

KIERAN, MW ;

CHAN, FY ;

BARONE, LM ;

YEE, K ;

RUNDSTADLER, JA ;

PRATT, S ;

RANSOM, D ;

ZON, LI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10713-10717

[20] Zebrafish scl functions independently in hematopoietic and endothelial development [J].

Dooley, KA ;

Davidson, AJ ;

Zon, LI .

DEVELOPMENTAL BIOLOGY, 2005, 277 (02) :522-536

← 1 2 3 4 5 6 7 8 9 10 →