Zebrafish as a model for myelopoiesis during embryogenesis

被引：52

作者：

Berman, JN

Kanki, JP

Look, AT

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Childrens Hosp, Boston, MA 02115 USA

来源：

EXPERIMENTAL HEMATOLOGY | 2005年 / 33卷 / 09期

关键词：

D O I：

10.1016/j.exphem.2005.06.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Zebrafish produce nearly identical hematopoeitic cell lineages to those found in mammals and other higher vertebrates. As in mammals, blood cell development proceeds in distinct waves, constituting embryonic (primitive) and adult (definitive) hematopoiesis. The conservation of genes such as scl, pu.1, clebp alpha, mpo, l-plastic, and lysozyme C in myelopoiesis and the corresponding expression patterns in zebrafish suggests that shared genetic pathways regulate this complex developmental process. In the zebrafish model system, experimental approaches have been applied, including RNA in situ hybridzation, morpholino injections, and the analysis of mutant and transgenic fish lines, leading to improved understanding of the regulation in vivo of key molecular pathways with conserved roles in vertebrate myelopoiesis. (c) 2005 International Society for Experimental Hematology. Published by Elsevier Inc.

引用

收藏

页码：997 / 1006

页数：10

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