Expression localization of Bmi1 in mice testis

被引：15

作者：

Zhang, Shiqing ^{[1
,2
]}

Li, Dexue ^{[1
]}

Li, Enzhong ^{[1
,3
]}

Li, Lan ^{[4
]}

Wang, Junjun ^{[5
]}

Wang, Changyong ^{[1
]}

Lu, Jingyan ^{[2
]}

Zhang, Xuerning ^{[3
]}

机构：

[1] Inst Basic Med Sci, Beijing 100850, Peoples R China

[2] Jilin Univ, Biol Tech Dept, Changchun 130062, Jilin, Peoples R China

[3] Huanghuai Univ, Zhumadian 463000, Henan, Peoples R China

[4] Eastern St Hosp, Beijing 100071, Peoples R China

[5] China Agr Univ, State Key Lab Anim Nutr, Beijing 100094, Peoples R China

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2008年 / 287卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

testis; spermatogonial stem cells; Bmi1; RNAi;

D O I：

10.1016/j.mce.2008.01.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

B cell-specific Moloney murine leukaemia virus integration site 1 (Bmi1), known as the first functional member of PcG (Polycomb Group) family, is supposed to be a key regulator of stem cell self-proliferation. In this study, we investigated its expression in testis and its impact on spermatogonia proliferation for better understanding of its role in spermatogenesis. Results showed that Bmil was expressed in undifferentiated spermatogonia (A(s), A(pr) and A(al), spermatogonia). Overexpression of BMI1 could promote spermatogonia proliferation, while repression of endogenous Bmi1 by RNAi resulted in inhibition of the proliferation. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：47 / 56

页数：10

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