High-throughput proteomics using Fourier transform ion cyclotron resonance mass spectrometry

被引：42

作者：

Qian, WJ

Camp, DG

Smith, RD ^{[1
]}

机构：

[1] Pacific NW Natl Lab, Div Biol Sci, Richland, WA 99352 USA

[2] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA

来源：

EXPERT REVIEW OF PROTEOMICS | 2004年 / 1卷 / 01期

关键词：

accurate mass and time tag; FTICR; high throughput; liquid chromatography; mass spectrometry; proteomics; stable isotype labeling;

D O I：

10.1586/14789450.1.1.87

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The advent of high-throughput proteomic technologies for global detection and quantitation of proteins creates new opportunities and challenges for those seeking to gain greater understanding of the cellular machinery. Here, recent advances in high resolution capillary liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry are reviewed along with its potential application to high-throughput proteomics. These technological advances combined with quantitative stable isotope labeling methodologies provide powerful tools for expanding our understanding of biology at the system level.

引用

收藏

页码：87 / 95

页数：9

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