Dopaminergic influences on formation of a motor memory

被引:147
作者
Flöel, A
Breitenstein, C
Hummel, F
Celnik, P
Gingert, C
Sawaki, L
Knecht, S
Cohen, LG
机构
[1] NINDS, Human Cort Physiol Sect, NIH, Bethesda, MD 20817 USA
[2] Univ Munster, Dept Neurol, D-4400 Munster, Germany
[3] Wake Forest Univ, Sch Med, Winston Salem, NC 27109 USA
关键词
D O I
10.1002/ana.20536
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The ability of the central nervous system to form motor memories, a process contributing to motor learning and skill acquisition, decreases with age. Dopaminergic activity, one of the mechanisms implicated in memory formation, experiences a similar decline with aging. It is possible that restoring dopaminergic function in elderly adults could lead to improved formation of motor memories with training. We studied the influence of a single oral dose of levodopa (100mg) administered preceding training on the ability to encode an elementary motor memory in the primary motor cortex of elderly and young healthy volunteers in a randomized, double-blind, placebo-controlled design. Attention to the task and motor training kinematics were comparable across age groups and sessions. In young subjects, encoding a motor memory under placebo was more prominent than in older subjects, and the encoding process was accelerated by intake of levodopa. In the elderly group, diminished motor memory encoding under placebo was enhanced by intake of levodopa to levels present in younger subjects. Therefore, upregulation of dopaminergic activity accelerated memory formation in young subjects and restored the ability to form a motor memory in elderly subjects; possible mechanisms underlying the beneficial effects of dopaminergic agents on motor learning in neurorehabilitation.
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页码:121 / 130
页数:10
相关论文
共 54 条
[51]   CHARACTERIZATION OF THE DOPAMINERGIC INNERVATION OF THE PRIMATE FRONTAL-CORTEX USING A DOPAMINE-SPECIFIC ANTIBODY [J].
WILLIAMS, SM ;
GOLDMANRAKIC, PS .
CEREBRAL CORTEX, 1993, 3 (03) :199-222
[52]   Dopamine, learning and motivation [J].
Wise, RA .
NATURE REVIEWS NEUROSCIENCE, 2004, 5 (06) :483-494
[53]   Quantification of neuroreceptors in the living human brain .3. D-2-like dopamine receptors: Theory, validation, and changes during normal aging [J].
Wong, DF ;
Young, D ;
Wilson, PD ;
Meltzer, CC ;
Gjedde, A .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (03) :316-330
[54]   Changes in human motor cortex excitability induced by dopaminergic and anti-dopaminergic drugs [J].
Ziemann, U ;
Tergau, F ;
Bruns, D ;
Baudewig, J ;
Paulus, W .
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1997, 105 (06) :430-437