A tale of two plaques: convergent mechanisms of T-cell-mediated inflammation in psoriasis and atherosclerosis

被引：117

作者：

Armstrong, April W. ^{[1
]}

Voyles, Stephanie V.

Armstrong, Ehrin J. ^{[2
]}

Fuller, Erin N. ^{[3
]}

Rutledge, John C. ^{[2
]}

机构：

[1] Univ Calif Davis, Dept Dermatol, Dermatol Clin Res Unit, Teledermatol Program, Davis, CA 95816 USA

[2] Univ Calif Davis, Div Cardiovasc Med, Davis, CA 95816 USA

[3] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA

来源：

EXPERIMENTAL DERMATOLOGY | 2011年 / 20卷 / 07期

关键词：

atherosclerosis; psoriasis; regulatory T cells; T-helper; 1; cells; 17; ACUTE CORONARY SYNDROMES; NECROSIS-FACTOR-ALPHA; GROWTH-FACTOR-BETA; INDEPENDENT RISK-FACTOR; TGF-BETA; INTERLEUKIN (IL)-22; CARDIOVASCULAR RISK; INTERFERON-GAMMA; DOWN-REGULATION; ARTERY-DISEASE;

D O I：

10.1111/j.1600-0625.2011.01308.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis and atherosclerosis are diseases in which effector T lymphocytes such as Helper T cells type 1 (Th1) and 17 (Th17) play integral roles in disease pathogenesis and progression. Regulatory T cells (Treg) also exert clinically important anti-inflammatory effects that are pathologically altered in psoriasis and atherosclerosis. We review the immunological pathways involving Th1, Th17 and Treg cells that are common to psoriasis and atherosclerosis. These shared pathways provide the basis for mechanisms that may explain the epidemiologic observation that patients with psoriasis have an increased risk of heart disease. Improved understanding of these pathways will guide future experiments and may lead to the development of therapeutics that prevent or treat cardiovascular complications in patients with psoriasis.

引用

页码：544 / 549

页数：6

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