Cytokine network and T cell immunity in atherosclerosis

被引：63

作者：

Ait-Oufella, Hafid ^{[1
,2
]}

Taleb, Soraya ^{[1
,2
]}

Mallat, Ziad ^{[1
,2
]}

Tedgui, Alain ^{[1
,2
]}

机构：

[1] INSERM, Paris Cardiovasc Res Ctr, F-75015 Paris, France

[2] Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2009年 / 31卷 / 01期

关键词：

Atherosclerosis; Immunity; Inflammation; Lymphocytes; Cytokines; RECEPTOR-DEFICIENT MICE; TGF-BETA; DENDRITIC CELLS; TRANSCRIPTION FACTOR; ORAL TOLERANCE; REDUCES ATHEROSCLEROSIS; PLAQUE PHENOTYPE; TARGET GENES; B-CELLS; INTERLEUKIN-10;

D O I：

10.1007/s00281-009-0143-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and adaptive immune responses contribute to disease initiation and progression. Recent studies established that subtypes of T cells, regulatory T cells (Tregs), actively involved in the maintenance of immunological tolerance, inhibit the development and progression of atherosclerosis. Here, we review the current knowledge on the Treg response and the major cytokines involved in its modulation in the context of atherosclerosis.

引用

页码：23 / 33

页数：11

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