Quantification of biological aging in young adults

被引：651

作者：

Belsky, Daniel W. ^{[1
,2
]}

Caspi, Avshalom ^{[3
,4
,5
,6
]}

Houts, Renate ^{[3
]}

Cohen, Harvey J. ^{[1
]}

Corcoran, David L. ^{[5
]}

Danese, Andrea ^{[6
,7
]}

Harrington, HonaLee ^{[3
]}

Israel, Salomon ^{[8
]}

Levine, Morgan E. ^{[9
]}

Schaefer, Jonathan D. ^{[3
]}

Sugden, Karen ^{[3
]}

Williams, Ben ^{[3
]}

Yashin, Anatoli I. ^{[2
]}

Poulton, Richie ^{[10
]}

Moffitt, Terrie E. ^{[3
,4
,5
,6
]}

机构：

[1] Duke Univ, Sch Med, Dept Med, Durham, NC 27710 USA

[2] Duke Univ, Social Sci Res Inst, Durham, NC 27708 USA

[3] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA

[4] Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Durham, NC 27708 USA

[5] Duke Univ, Ctr Genom & Computat Biol, Durham, NC 27708 USA

[6] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London SE5 8AF, England

[7] Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London SE5 8AF, England

[8] Hebrew Univ Jerusalem, Dept Psychol, IL-91905 Jerusalem, Israel

[9] Univ Calif Los Angeles, David Geffen Sch Med, Gonda Res Ctr, Dept Human Genet, Los Angeles, CA 90095 USA

[10] Univ Otago, Dept Psychol, Dunedin 9016, New Zealand

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2015年 / 112卷 / 30期

基金：

英国医学研究理事会;

关键词：

biological aging; cognitive aging; aging; healthspan; geroscience; RETINAL VASCULAR CALIBER; CREATININE CLEARANCE; VESSEL DIAMETERS; ALLOSTATIC LOAD; NORMATIVE DATA; AGE; BIOMARKER; STRENGTH; HEALTH; ABNORMALITIES;

D O I：

10.1073/pnas.1506264112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. We developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. Our longitudinal measure allows quantification of the pace of coordinated physiological deterioration across multiple organ systems (e.g., pulmonary, periodontal, cardiovascular, renal, hepatic, and immune function). We applied these methods to assess biological aging in young humans who had not yet developed age-related diseases. Young individuals of the same chronological age varied in their "biological aging" (declining integrity of multiple organ systems). Already, before midlife, individuals who were aging more rapidly were less physically able, showed cognitive decline and brain aging, self-reported worse health, and looked older. Measured biological aging in young adults can be used to identify causes of aging and evaluate rejuvenation therapies.

引用

页码：E4104 / E4110

页数：7

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