Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, So ce1525

被引：45

作者：

Gerth, Klaus ^{[1
]}

Steinmetz, Heinrich ^{[1
]}

Hoefle, Gerhard ^{[1
]}

Jansen, Rolf ^{[1
]}

机构：

[1] Helmholtz Zentrum Infekt Forsch, D-38124 Braunschweig, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 03期

关键词：

halogenated compounds; myxobacteria; polyketides; structure elucidation;

D O I：

10.1002/anie.200703993

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Previously unknown: gem-Dichloro-1,3-diones were unprecedented as natural compounds, but chlorotonil A (1) features this functionality in a 14-membered lactone ring. Compound 1 was isolated from the myxobacterium Sorangium cellulosum and its structure elucidated. The poor solubility of 1 in both organic solvents and water again raises the old question of why bacteria create such complex metabolites. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：600 / 602

页数：3

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