Improved picture naming in chronic aphasia after TMS to part of right Broca's area: An open-protocol study

被引：406

作者：

Naeser, MA

Martin, PI

Nicholas, M

Baker, EH

Seekins, H

Kobayashi, M

Theoret, H

Fregni, F

Maria-Tormos, J

Kurland, J

Doron, KW

Pascual-Leone, A

机构：

[1] VA Boston Healthcare Syst 12A, Boston, MA 02130 USA

[2] Boston Univ, Sch Med, Aphasia Res Ctr, Dept Neurol, Boston, MA 02118 USA

[3] Harvard Univ, Sch Med, Dept Neurol, Ctr Noninvas Brain Simulat, Cambridge, MA 02138 USA

[4] Beth Israel Deaconess Med Ctr, Boston, MA USA

[5] Univ Montreal, Hop St Justine, Montreal, PQ H3T 1C5, Canada

[6] Univ Montreal, Dept Psychol, Montreal, PQ H3C 3J7, Canada

[7] Univ Autonoma Barcelona, Inst Univ, Inst Guttmann Neurorehabil, E-08193 Barcelona, Spain

来源：

BRAIN AND LANGUAGE | 2005年 / 93卷 / 01期

关键词：

aphasia; TMS; naming; stroke rehabilitation;

D O I：

10.1016/j.bandl.2004.08.004

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Functional imaging studies with nonfluent aphasia patients have observed "over-activation" in right (R) language homologues. This may represent a maladaptive strategy; suppression may result in language improvement. We applied slow, 1 Hz repetitive transcranial magnetic stimulation (rTMS) to an anterior portion of R Broca's homologue daily, for 10 days in four aphasia patients who were 5-11 years poststroke. Significant improvement was observed in picture naming at 2 months post-rTMS, with lasting benefit at 8 months in three patients. This preliminary, open trial suggests that rTMS may provide a novel treatment approach for aphasia by possibly modulating the distributed, bi-hemispheric language network. Published by Elsevier Inc.

引用

页码：95 / 105

页数：11

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