Lactarane sesquiterpenoids from Lactarius subvellereus and their cytotoxicity

被引：29

作者：

Kim, Ki Hyun ^{[1
]}

Noh, Hyung Jun ^{[1
]}

Choi, Sang Un ^{[2
]}

Park, Ki Moon ^{[3
]}

Seok, Soon-Ja ^{[4
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 440746, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[3] Sungkyunkwan Univ, Dept Food Sci & Biotechnol, Suwon 440746, South Korea

[4] Natl Inst Agr Sci & Technol, RDA, Div Appl Microbiol, Suwon 441707, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 18期

关键词：

Lactarius subvellereus; Russulaceae; Lactarane sesquiterpenoid; Cytotoxicity; FUNGAL METABOLITES; MACROLEPIOTA-NEOMASTOIDEA; CONSTITUENTS;

D O I：

10.1016/j.bmcl.2010.07.119

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Subvellerolactones B (1), D (2), and E (3), structurally unusual lactarane sesquiterpenoids, were isolated from the fruiting bodies of Lactarius subvellereus together with four known lactarane sesquiterpenes (4-7). The chemical structures and stereochemistries of compounds 1-3 were determined on the basis of spectroscopic analyses, including 1D and 2D NMR experiments and a convenient Mosher ester procedure. Subvellerolactone B (1) exhibited cytotoxicity against the A549, SK-MEL-2, and HCT-15 cell lines with IC50 values of 26.5, 18.3, and 14.2 mu M, respectively, and subvellerolactones D (2) and E (3) showed cytotoxicity against the A549 and HCT-15 cell lines (IC50 (2): 25.1 and 17.8 mu M, and IC50 (3): 19.6 and 28.7 mu M, respectively). (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5385 / 5388

页数：4

共 14 条

[1]

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[2]

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