Cysteine dioxygenase: regional expression of activity in rat brain

被引：12

作者：

Parsons, RB ^{[1
]}

Barber, PC

Waring, RH

Williams, AC

Ramsden, DB

机构：

[1] Univ Birmingham, Dept Med, Birmingham B15 2TH, W Midlands, England

[2] Univ Birmingham, Dept Clin Neurosci, Birmingham B15 2TH, W Midlands, England

[3] Univ Birmingham, Dept Biochem, Birmingham B15 2TT, W Midlands, England

[4] Univ Birmingham, Dept Anat, Birmingham B15 2TT, W Midlands, England

来源：

NEUROSCIENCE LETTERS | 1998年 / 248卷 / 02期

关键词：

cysteine dioxygenase; rat; brain; cysteine; neurotoxicity; methionine;

D O I：

10.1016/S0304-3940(98)00343-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The levels of expression of cysteine dioxygenase (CDO) protein and activity were investigated in nine functionally distinct regions of the rat brain before and after induction with methionine by Western analysis and an activity assay. Activity expression ranged from no activity in the brain-stem to high activity expression in the olfactory bulb and basal ganglia. Upon exposure to 400 mg/l methionine for 5 days, significant induction of expression was observed in the basal ganglia, brain-stem, cerebellum, hippocampus, midbrain and olfactory bulb. Protein expression appeared to correlate with activity expression when levels before and after induction were compared. This non-uniformity of expression may reflect different physiological functions of CDO in these areas. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：101 / 104

页数：4

共 21 条

[1]

BOSS V, 1994, MOL PHARMACOL, V45, P1177

[2]

Hilgier W, 1996, J NEUROSCI RES, V45, P69, DOI 10.1002/(SICI)1097-4547(19960701)45:1<69::AID-JNR6>3.0.CO

[3]

2-F

[4] DETERMINATION OF CYSTEINESULFINATE, HYPOTAURINE AND TAURINE IN PHYSIOLOGICAL SAMPLES BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

HIRSCHBERGER, LL ;

DELAROSA, J ;

STIPANUK, MH .

JOURNAL OF CHROMATOGRAPHY, 1985, 343 (02) :303-313

[5]

Ho SL, 1996, ADV NEUROL, V69, P53

[6] ISOLATION AND CHARACTERIZATION OF A CDNA FOR RAT-LIVER CYSTEINE DIOXYGENASE [J].

HOSOKAWA, Y ;

MATSUMOTO, A ;

OKA, J ;

ITAKURA, H ;

YAMAGUCHI, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 168 (02) :473-478

[7] Chromosomal localisation of genes coding for human and mouse liver cytosolic cysteine dioxygenase [J].

Jeremiah, S ;

McCann, KP ;

Williams, AC ;

Ramsden, DB ;

Pilz, AJ ;

Fox, MF ;

Povey, S .

ANNALS OF HUMAN GENETICS, 1996, 60 :29-33

[8] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4 [J].

LAEMMLI, UK .

NATURE, 1970, 227 (5259) :680-+

[9]

LEININGERMULLER B, 1994, THERAPIE, V49, P499

[10]

Li H, 1997, J NEUROCHEM, V69, P1530

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