Toward a final design for the Birmingham boron neutron capture therapy neutron beam

被引:9
作者
Allen, DA [1 ]
Beynon, TD
Green, S
James, ND
机构
[1] Univ Birmingham, Sch Phys & Astron, Birmingham B15 2TT, W Midlands, England
[2] Queen Elizabeth Hosp, Dept Med Phys, Birmingham B15 2TH, W Midlands, England
[3] Univ Birmingham, CRC, Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
关键词
BNCT; accelerator; Monte Carlo; epithermal neutrons; MCNP;
D O I
10.1118/1.598480
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
This paper is concerned with the proposed Birmingham accelerator-based epithermal neutron beam for boron neutron capture therapy (BNCT). Details of the final moderator design, such as beam delimiter, shield, and beam exit surface shape are considered. Monte Carlo radiation transport simulations with a head and body phantom have shown that a simple flat moderator beam exit surface is preferable to the previously envisioned spherical design. Dose rates to individual body organs during treatment have been calculated using a standard MIRD phantom. We have shown that a simple polyethylene shield, doped with natural lithium, is sufficient to provide adequate protection to the rest of the body during head irradiations. The effect upon the head phantom dose distributions of the use of such a shield to delimit the therapy beam has been evaluated. (C) 1999 American Association of Physicists in Medicine. [S0094-2405(99)00801-9].
引用
收藏
页码:77 / 82
页数:6
相关论文
共 16 条
[11]   An improved neutron collimator for brain tumor irradiations in clinical boron neutron capture therapy [J].
Liu, HB ;
Greenberg, DD ;
Capala, J ;
Wheeler, FJ .
MEDICAL PHYSICS, 1996, 23 (12) :2051-2060
[12]   RESPONSE OF THE CENTRAL-NERVOUS-SYSTEM TO BORON NEUTRON-CAPTURE IRRADIATION - EVALUATION USING RAT SPINAL-CORD MODEL [J].
MORRIS, GM ;
CODERRE, JA ;
HOPEWELL, JW ;
MICCA, PL ;
NAWROCKY, MM ;
LIU, HYB ;
BYWATERS, A .
RADIOTHERAPY AND ONCOLOGY, 1994, 32 (03) :249-255
[13]   LATE EFFECTS OF NORMAL-TISSUES CONSENSUS CONFERENCE [J].
RUBIN, P .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 31 (05) :1035-1036
[14]  
SNYDER WS, 1969, J NUCL MED MIRD S, V3
[15]   TREATMENT PLANNING FIGURES OF MERIT IN THERMAL AND EPITHERMAL BORON NEUTRON-CAPTURE THERAPY OF BRAIN-TUMORS [J].
WALLACE, SA ;
MATHUR, JN ;
ALLEN, BJ .
PHYSICS IN MEDICINE AND BIOLOGY, 1994, 39 (05) :897-906
[16]  
ZAMENHOF RG, NEUTRON BEAM DESIGN, P283