Citrus aurantium Naringenin Prevents Osteosarcoma Progression and Recurrence in the Patients Who Underwent Osteosarcoma Surgery by Improving Antioxidant Capability

被引：30

作者：

Zhang, Lirong ^{[1
]}

Xu, Xiaohua ^{[2
]}

Jiang, Tiechao ^{[3
]}

Wu, Kunzhe ^{[4
]}

Ding, Chuanbo ^{[5
]}

Liu, Zhen ^{[6
]}

Zhang, Xuanhe ^{[7
]}

Yu, Tianhua ^{[8
]}

Song, Changlong ^{[9
]}

机构：

[1] Jilin Univ, Dept Pathol, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

[2] Jilin Univ, Dept Nephrol, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

[3] Jilin Univ, Cardiol Dept, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

[4] China Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 4, Shenyang 110032, Liaoning, Peoples R China

[5] Jilin Agr Univ, Coll Chinese Med Mat, Teaching Off, Changchun 130118, Jilin, Peoples R China

[6] Liuhe Dist Hosp Nanjing, Pediat, Nanjing 211500, Jiangsu, Peoples R China

[7] Shihezi Univ, Shihezi 832003, Peoples R China

[8] Jilin Univ, Blood Transfus Dept, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

[9] Jilin Univ, Breast Surg Dept, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2018年 / 2018卷

关键词：

CAROTENE CANCER PREVENTION; CELL-CYCLE ARREST; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; BREAST-CANCER; FLAVONOIDS HESPERIDIN; SIGNALING PATHWAYS; GROWTH-INHIBITION; COLON-CANCER; FOLLOW-UP;

D O I：

10.1155/2018/8713263

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Citrus aurantium is rich in flavonoids, which may prevent osteosarcoma progression, but its related molecular mechanism remains unclear. Flavonoids were extracted from C. aurantium and purified by reparative HPLC. Each fraction was identified by using electrospray ionisation mass spectrometry (ESI-MS). Three main components (naringin, naringenin, and hesperetin) were isolated from C. aurantium. Naringenin inhibited the growth of MG-63 cells, whereas naringin and hesperetin had no inhibitory function on cell growth. ROS production was increased in naringin-and hesperetin-treated groups after one day of culture while the level was always lowest in the naringenin-treated group after three days of culture. 95 osteosarcoma patients who underwent surgery were assigned into two groups: naringenin group (NG, received 20 mg naringenin daily, n = 47) and control group (CG, received 20 mg placebo daily, n = 48). After an average of two-year follow-up, osteosarcoma volumes were smaller in the NG group than in the CG group (P > 0.01). The rate of osteosarcoma recurrence was also lower in the NG group than in CG group. ROS levels were lower in the NG group than in the CG group. Thus, naringenin from Citrus aurantium inhibits osteosarcoma progression and local recurrence in the patients who underwent osteosarcoma surgery by improving antioxidant capability.

引用

页数：16

共 55 条

[51]

Pharmacokinetics and pharmacodynamics of liposomal mifamurtide in adult volunteers with mild or moderate hepatic impairment [J].