Steroidal saponins from the leaves of Cestrum sendtenerianum

被引：50

作者：

Haraguchi, M

Mimaki, Y

Motidome, M

Morita, H

Takeya, K

Itokawa, H

Yokosuka, A

Sashida, Y

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

[2] Univ Sao Paulo, Inst Quim, BR-05508900 Sao Paulo, Brazil

[3] Inst Biol, Ctr Sanidade Anim, BR-04014002 Sao Paulo, Brazil

来源：

PHYTOCHEMISTRY | 2000年 / 55卷 / 07期

关键词：

Cestrum sendtenerianum; Solanaceae; spirostanol saponins; cytotoxic activity; HL-60; cells;

D O I：

10.1016/S0031-9422(00)00109-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Five steroidal saponins were isolated from the EtOH extract of Cestrum sendtenerianum (Solanaceae), as confirmed by detailed analysis of their H-1, C-13, and two-dimensional NMR spectral data, and by the results of hydrolytic cleavage. The saponins were revealed to contain three hydroxyl groups at the C-1 beta, C-2 alpha, and C-3 beta positions in the spirostanol skeleton, and to bear a di- or triglycoside at C-3 as the common structural features. One of the compounds, a spirostanol triglycoside, showed weak cytotoxic activity on HL-60 human promyelocytic leukemia cells, with an IC50 value of 7.7 mug/ml. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：715 / 720

页数：6

共 11 条

[1]

NMR-SPECTROSCOPY IN THE STRUCTURAL ELUCIDATION OF OLIGOSACCHARIDES AND GLYCOSIDES [J].