Endothelin receptors in testosterone-induced prostatic hypertrophy in rats

被引:8
作者
Auger-Pourmarin, L [1 ]
Roubert, P [1 ]
Chabrier, PE [1 ]
机构
[1] Inst Henri Beaufour, F-91966 Les Ulis, France
关键词
prostate; endothelin receptor; testosterone;
D O I
10.1254/jjp.77.307
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Endothelin receptors were characterized in rat prostate and potential modification of these receptors was investigated in prostatic hypertrophy induced by testosterone. Both ETA and ETB endothelin receptor mRNA were detected in rat prostate, whereas binding experiments show the presence of only ETA receptors. Testosterone administration produced a 75% increase in prostate weight. Although the density of prostatic endothelin receptors was decreased from 348 +/- 75.0 fmol/mg protein in control rats to 252 +/- 39.9 fmol/mg protein in testosterone-treated animals, the total amount of receptors per prostate was unchanged. The steady-state level of ETA- and ETB-receptormRNA was not altered by testosterone treatment. These results suggest that endothelin receptors are not affected in prostatic hypertrophy induced by testosterone.
引用
收藏
页码:307 / 310
页数:4
相关论文
共 15 条
[1]  
CAINE M, 1990, UROL CLIN N AM, V17, P641
[2]  
KOBAYASHI S, 1994, MOL PHARMACOL, V45, P306
[3]   LOCALIZATION OF ENDOTHELIN RECEPTORS IN THE HUMAN PROSTATE [J].
KOBAYASHI, S ;
TANG, R ;
WANG, B ;
OPGENORTH, T ;
STEIN, E ;
SHAPIRO, E ;
LEPOR, H .
JOURNAL OF UROLOGY, 1994, 151 (03) :763-766
[4]   ENDOTHELIN RECEPTOR DENSITY IN HUMAN HYPERTROPHIC AND NON-HYPERTROPHIC PROSTATE TISSUE [J].
KONDO, S ;
MORITA, T ;
TASHIMA, Y .
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 172 (04) :381-384
[5]   ENDOTHELIN-1 IN THE HUMAN PROSTATE - TISSUE-LEVELS, SOURCE OF PRODUCTION AND ISOMETRIC TENSION STUDIES [J].
LANGENSTROER, P ;
TANG, R ;
SHAPIRO, E ;
DIVISH, B ;
OPGENORTH, T ;
LEPOR, H .
JOURNAL OF UROLOGY, 1993, 150 (02) :495-499
[6]  
LeBrun G, 1996, PROSTATE, V28, P379
[7]   INFRAVESICAL OUTFLOW OBSTRUCTION IN RATS - A COMPARISON OF 2 MODELS [J].
MAGGI, CA ;
MANZINI, S ;
GIULIANI, S ;
MELI, A .
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1989, 20 (03) :345-349
[8]   Decreased contractile effect of endothelin-1 on hyperplastic prostate [J].
Moriyama, N ;
Kurimoto, S ;
Miyata, N ;
Yamaura, H ;
Yamazaki, R ;
Sudoh, K ;
Inagaki, O ;
Takenaka, T ;
Kawabe, K .
GENERAL PHARMACOLOGY, 1996, 27 (06) :1061-1065
[9]  
Nelson JB, 1996, CANCER RES, V56, P663
[10]   Pharmacological characterization of the isolated canine prostate [J].
Normandin, DE ;
Lodge, NJ .
JOURNAL OF UROLOGY, 1996, 155 (05) :1758-1761