Endothelin receptors in testosterone-induced prostatic hypertrophy in rats

被引：8

作者：

Auger-Pourmarin, L ^{[1
]}

Roubert, P ^{[1
]}

Chabrier, PE ^{[1
]}

机构：

[1] Inst Henri Beaufour, F-91966 Les Ulis, France

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 77卷 / 04期

关键词：

prostate; endothelin receptor; testosterone;

D O I：

10.1254/jjp.77.307

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endothelin receptors were characterized in rat prostate and potential modification of these receptors was investigated in prostatic hypertrophy induced by testosterone. Both ETA and ETB endothelin receptor mRNA were detected in rat prostate, whereas binding experiments show the presence of only ETA receptors. Testosterone administration produced a 75% increase in prostate weight. Although the density of prostatic endothelin receptors was decreased from 348 +/- 75.0 fmol/mg protein in control rats to 252 +/- 39.9 fmol/mg protein in testosterone-treated animals, the total amount of receptors per prostate was unchanged. The steady-state level of ETA- and ETB-receptormRNA was not altered by testosterone treatment. These results suggest that endothelin receptors are not affected in prostatic hypertrophy induced by testosterone.

引用

页码：307 / 310

页数：4

共 15 条

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