The Transcription Factor GATA3 Controls Cell Fate and Maintenance of Type 2 Innate Lymphoid Cells

被引：713

作者：

Hoyler, Thomas ^{[1
,2
]}

Klose, Christoph S. N. ^{[1
,3
]}

Souabni, Abdallah ^{[4
]}

Turqueti-Neves, Adriana ^{[5
,6
]}

Pfeifer, Dietmar ^{[7
]}

Rawlins, Emma L. ^{[8
]}

Voehringer, David ^{[5
,6
]}

Busslinger, Meinrad ^{[4
]}

Diefenbach, Andreas ^{[1
,2
,3
,9
]}

机构：

[1] Univ Freiburg, IMMH, D-79104 Freiburg, Germany

[2] Univ Freiburg, Res Training Grp Organogenesis GRK1104, D-79104 Freiburg, Germany

[3] Univ Freiburg, Spemann Grad Sch Biol & Med, D-79104 Freiburg, Germany

[4] Vienna Bioctr, Res Inst Mol Pathol, A-1020 Vienna, Austria

[5] Univ Erlangen Nurnberg, D-91054 Erlangen, Germany

[6] Univ Klinikum Erlangen, Inst Med Microbiol Immunol & Hyg, Dept Infect Biol, D-91054 Erlangen, Germany

[7] Univ Freiburg, Med Ctr Freiburg, Dept Internal Med 1, Core Facil Genom, D-79106 Freiburg, Germany

[8] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England

[9] Univ Freiburg, BIOSS Ctr Biol Signalling Studies, D-79104 Freiburg, Germany

来源：

IMMUNITY | 2012年 / 37卷 / 04期

关键词：

FUNCTION-ASSOCIATED ANTIGEN; ROR-GAMMA-T; CUTTING EDGE; KILLER-CELL; EXPRESSION; HOMEOSTASIS; POPULATION; IMMUNITY; CADHERIN; FAMILY;

D O I：

10.1016/j.immuni.2012.06.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate lymphoid cells (ILCs) reside at mucosal surfaces and control immunity to intestinal infections. Type 2 innate lymphoid cells (ILC2s) produce cytokines such as IL-5 and IL-13, are required for immune defense against helminth infections, and are involved in the pathogenesis of airway hyperre-activity. Here, we have investigated the role of the transcription factor GATA-3 for ILC2 differentiation and maintenance. We showed that ILC2s and their lineage-specified bone marrow precursors (ILC2Ps), as identified here, were characterized by continuous high expression of GATA-3. Analysis of mice with temporary deletion of GATA-3 in all ILCs showed that GATA-3 was required for the differentiation and maintenance of ILC2s but not for ROR gamma t(+) ILCs. Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates.

引用

页码：634 / 648

页数：15

共 40 条

[1]

Blaser C, 1998, J IMMUNOL, V161, P6451

[2] Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity [J].