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Effect of interferon-lambda on replication of hepatitis B virus in human hepatoma cells

被引：61
作者：
Hong, Seung-Ho
Cho, Okki
Kim, Koyngmin
Shin, Ho-Joon
Kotenko, Sergei V.
Park, Sun
机构：
[1] Ajou Univ, Sch Med, Dept Microbiol, Suwon 442749, South Korea
[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Biochem & Mol Biol, Newark, NJ 07103 USA
来源：
VIRUS RESEARCH | 2007年 / 126卷 / 1-2期
关键词：
hepatitis B virus; interleukin; 29; proteins; virus replication; receptors; interferon;
D O I：
10.1016/j.virusres.2007.03.006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The antiviral activity of interferon-lambda (IFN-lambda) against several viruses has been reported, but it has not been investigated whether human IFN-lambda can affect replication of the hepatitis B virus (HBV) in human hepatocyte-derived cells. We found that replication of HBV in a human hepatoma cell line was reduced by approximately 30% following treatment with a high concentration of IFN-lambda. Furthermore, we showed that replication of HBV in another human hepatoma cell line was not suppressed by IFN-lambda. However, these cell lines showed a similar level of transcription for the heterodimeric IFN-lambda receptor and the IFN-lambda-induced antiviral proteins. Our results suggest that the antiviral activity of IFN-lambda against HBV may be limited in human cells. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：245 / 249
页数：5
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