NOTCH SIGNALING IN THE VASCULATURE

被引:201
作者
Gridley, Thomas [1 ]
机构
[1] Jackson Lab, Bar Harbor, ME 04609 USA
来源
NOTCH SIGNALING | 2010年 / 92卷
关键词
SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-GROWTH-FACTOR; BRAIN ARTERIOVENOUS-MALFORMATIONS; AUTOSOMAL-DOMINANT ARTERIOPATHY; INHIBITS TUMOR-GROWTH; AMYLOID PRECURSOR PROTEIN; TRANSGENIC MOUSE MODEL; TRANSCRIPTION FACTORS; EMBRYONIC LETHALITY; SUBCORTICAL INFARCTS;
D O I
10.1016/S0070-2153(10)92009-7
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Notch signaling is an evolutionarily conserved, intercellular signaling mechanism that plays myriad roles during vascular development and physiology in vertebrates. These roles include the regulation of arteriovenous specification and differentiation in both endothelial cells and vascular smooth muscle cells, regulation of blood vessel sprouting and branching during normal and pathological angiogenesis, and the physiological responses of vascular smooth muscle cells. Defects in Notch signaling also cause inherited vascular diseases, such as the degenerative vascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. This review summarizes recent studies that highlight the multiple roles the Notch signaling pathway plays during vascular development and physiology.
引用
收藏
页码:277 / 309
页数:33
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